Health Condition 1: null- Cirrhosis with Variceal bleeding
Conditions
Interventions
Intervention1: Standard therapy arm: FFP and Platelets transfusion as per standard guidelines
Control Intervention1: TEG therapy arm: FFP and Platelets transfusion without TEG guided
Sponsors
Department of Gastroenterology AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Cirrhosis with acute variceal bleeding 2. Age between 18-65 years 3. Willing to participate in the study
Exclusion criteria
Exclusion criteria: 1. Variceal bleeding secondary to causes other than cirrhosis. eg, extrahepatic venous obstruction, hepatic venous outflow track obstruction 2. Patients with malignancy/disseminated intravascular coagulation (DIC)/known coagulopathic disorder (haemophilia) apart from cirrhosis. 3. History of intake of platelets inhibitors (eg, aspirin, clopidogrel) and drugs affecting coagulation cascade (eg, vitamin K anatagonists) within past 7 days 4. Pregnant women and those on oral contraceptives 5. Patients with chronic renal failure 6. History of underlying hypercoagulable/ hypocoagulable states eg. paroxysmal nocturnal hemoglobunuria (PNH), polycythemia vera etc 7. Patients receiving blood products (fresh frozen plasma and platelet prior to thromboelastography) 8. Patients with shock 9. Sepsis 10. Acute on chronic liver failure 11. Hepatorenal syndrome 12. Hepatic encephalopathy 13. Contraindication to endoscopy 14. Not willing to provide consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in the requirement of blood products between the two groups.Timepoint: 24 hours, 120 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Control of variceal bleeding at 24 hours and 5 days. 2. Rebleeding and mortality at 6 weeks. Timepoint: 1. Control of variceal bleeding at 24 hours and 5 days. 2. Rebleeding and mortality at 6 weeks. | — |
Countries
India
Contacts
Public ContactDr Shalimar
AIIMS, New Delhi
Outcome results
None listed