Comparison of serum levels of cobalamine after giving a thrice weekly dose versus once weekly dose of methylcobalamin in patients suffering from peripheral neuropathy

A randomized, open labelled, study comparing the serum levels of cobalamin after three doses of 500 mcg vs. single dose methylcobalamin of 1500 mcg in patients of peripheral neuropathy

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2017/02/007804

Enrollment

Registered

2017-02-07

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Peripheral neuropathy

Interventions

Intervention1: Methylcobalamin injection: Methylcobalamine injection 500 microgram thrice weekly intramuscularly for 2 weeks Control Intervention1: Methylcobalamine injection: Methylcobalamine injecti

Eligibility

Inclusion criteria

Inclusion criteria: • Age > 18 years • Subjects diagnosed with peripheral neuropathy through nerve conduction velocity test or healthy volunteers • Ability to give written informed consent

Exclusion criteria

Exclusion criteria: • Females who are pregnant or lactating • History of clinically significant metabolic, hepatic, renal, haematological, pulmonary, cardiovascular, gastrointestinal, urological, neurological or psychiatric disorders

Design outcomes

Primary

Measure	Time frame
Serum Cobalmine levels after multiple and single dose of trial medicationsTimepoint: baseline Day 8 Day 15	—

Secondary

Measure	Time frame
adverse eventsTimepoint: at all visits;serum Homocysteine levelsTimepoint: baseline Day 8 Day 15	—

Countries

India

Contacts

Public ContactAmrita Sil

IPGME&R Kolkata

drsilamrita@gmail.com09477737091

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026