Health Condition 1: null- Adult acute lymphoblastic leukemia/Lymphoblastic lymphoma
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
Tata Memorial Centre
Eligibility
Inclusion criteria
Inclusion criteria: Newly diagnosed Patients of Acute lymphoblastic leukemia/lymphoblastic lymphoma aged >= 15 years. 2. Treated on standard ALL protocol such as BFM 90 protocol. 3. Occult Hepatitis B infection. 4. Normal Liver function tests (AST/ALT 5. Those who give a written informed consent.
Exclusion criteria
Exclusion criteria: Patients with Hepatitis C viral co-infection. 2. Patients with Human immunodeficiency virus co-infection. 3. Patients with history of Hepatitis B vaccination (if anti HBs titre is >5U/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk of Hepatitis B reactivationTimepoint: At baseline, at the end of week 4, week 8, week 20, 32, week 48, at the completion of maintenance, post 6 months of completion of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation Between baseline HBV DNA and risk of HBV reactivationTimepoint: 2 years;Delay in administration of Myelosuppressive chemotherapyTimepoint: during intensive phase;Incidence of CMV ViremiaTimepoint: During Intensive Phase;Incidence of HBV related HepatitisTimepoint: Upto 2 years on treatment;Incidence of OHBITimepoint: at Baseline | — |
Countries
India
Contacts
Public ContactDr Hasmukh Jain
Tata Memorial Hospital
Outcome results
None listed