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Role of serum biomarkers predicting neurological outcome in Birth asphyxia

ROLE OF SERUM BIOMARKERS IN PREDICTING NEUROLOGICAL OUTCOME AND MULTIORGAN DYSFUNCTION IN NEONATES â?¥ 36 WEEKS WITH BIRTH ASPHYXIA

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2017/01/007739
Enrollment
100
Registered
2017-01-25
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Collecting venous blood sample and assessing serum biomarkers assay for correlating with neurological outcome and multiorgan dysfunction.

Interventions

Intervention1: ROLE OF SERUM BIOMARKERS IN PREDICTING NEUROLOGICAL OUTCOME AND MULTIORGAN DYSFUNCTION IN NEONATES â?¥ 36 WEEKS WITH BIRTH ASPHYXIA: S protein 100 B,Cystatin-C,Cardiac troponin-I,and LD
USA, Cystatin-C-Diametra,Italy,,Cardiac troponin-I Blovendor,USA,andLDH - Roche )are obtained,values are recorded by Sandwich ELISA for S protein 100 B,Cystatin-C,Cardiac troponin-Iand LDH Spectrophot

Sponsors

Institute of Child Health and Hospital for Children
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria: Neonates born at >=36 weeks of gestation and > 1800 gm birth weight with perinatal asphyxia are eligible. Perinatal asphyxia in patients born at the study hospital or any other health facility was defined as the need for resuscitation at birth, along with the presence of one or more of the following. 1.Apgar score of birth, 2.Continued need for resuscitation, for > 5 mins 3.umbilical cord pH or any arterial pH of 60 min of birth and base deficit of >16 mmol/L within 60 min of birth

Exclusion criteria

Exclusion criteria: 1.Babies with Major congenital anomalies 2.Babies arriving after 24 hours of age completed 3. Babies enrolled in Therapeutic Cooling Study

Design outcomes

Primary

MeasureTime frame
To study correlation between s protein 100B,CARDIAC TROPONIN,CYSTATIN C,LDH with neurological outcome at 14 days and 90 days of ageTimepoint: 0,1,3,14,90 days—

Secondary

MeasureTime frame
To compare serum biomarkers against NICHD score in predicting neurological outcome. 6. Study of correlation between MODS and neurological outcome at 14 days/later and 3months of age 7. Neurological outcome at discharge by Hammersmith examination 8. To compare above serum biomarkers against Mortality rate Timepoint: 0,1,3,14,90 days—

Countries

India

Contacts

Public ContactDr CNKamalarathnam

Institute of Child Health and Hospital for Children

drkamal.rathnam@gmail.com09841102746

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026