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Comparison of two methods of pain relief after open gynecological cancer surgery - Bilateral rectus sheath block with multimodal analgesia versus intrathecal morphine

Postoperative analgesia for open midline incisions in gynaecological oncology surgery : Ultrasound guided bilateral rectus sheath block with multimodal analgesia versus intrathecal morphine

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2017/01/007730
Enrollment
90
Registered
2017-01-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Gynaecological cancer patients scheduled for open surgery

Interventions

Intervention1: Ultrasound guided bilateral rectus sheath block: 20 ml of 0.375% Ropivacaine in saline will be injected into the rectus sheath space on either side under direct ultrasound visualisation

Sponsors

Vimi Rewari
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion Criteria: • > 18 years of age •Planned major abdominal surgery for gynaecological cancer with open midline surgical incision •Willing and able to consent and communicate properly •American Society of Anaesthesiologists (ASA) I â?? III

Exclusion criteria

Exclusion criteria: Exclusion Criteria: •Consent refused •ASA >III •Contraindications to regional technique e.g allergy to local anaesthesia, infection around site of block , coagulation disorder and sepsis •History of analgesic dependence (long term use) and opiate tolerance •Difficulty with communication •Pre-existing chronic abdominal pain •Use of any analgesic (opioid, acetaminophen, NSAIDS) within 24 hours of surgery •Diabetes or Renal insufficiency •Concurrent additional surgery at another anatomical site •Extensive existing midline abdominal scarring

Design outcomes

Primary

MeasureTime frame
Total postoperative morphine consumption as administered by intravenous patient-controlled analgesia (PCA) in the Post Anaesthesia Care Unit (PACU)Timepoint: 24 hrs postoperatively—

Secondary

MeasureTime frame
1.Time to first request for analgesia or VAS (Visual Analogue Scale) 4 2.Pain scores as measured by the VAS score at rest and on movement (Flexion of legs at the knee joint) at 0, ½, 1, 2, 4, 6, 12 and 24 hours postoperatively 3.Incidence of side effects of opioids â?¢Respiratory depression , sedation, pruritus and postoperative nausea and vomiting 4.Time to return of intestinal function ( Passage of flatus) 5.Patient satisfaction with the analgesic regime Timepoint: 0, ½, 1, 2, 4, 6, 12 and 24 hours postoperatively—

Countries

India

Contacts

Public ContactVimi Rewari

AIIMS,New Delhi

alka.aiims08@gmail.com07042130984

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026