Health Condition 1: null- Pediatric Acute Respiratory Distress Syndrome(ARDS)
Conditions
Interventions
Intervention1: Leucoreduced Packed Red blood cell: GroupI Will receive PRBC if hemoglobin less than 7 gm/dl
Group II will receive PRBC if hemoglobin less than 9 gm/dl
Intervention2: Leukoreduced Packe
Sponsors
PGIMER CHANDIGARH
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 1 month- 12 years admitted to our hospital and satisfying the criteria for the diagnosis of ARDS based on the recent pediatric specific definition proposed by Pediatric Acute Lung Injury Consensus Conference Group investigators any time during the hospital stay and on invasive mechanical ventilation and having atleast one hemoglobin level less than 9 gm/dl within 1 week of diagnosis of ARDS with no exclusion criteria will be included in study. .
Exclusion criteria
Exclusion criteria: 1 Those who deny consent to participate in the study. 2 Patients with cyanotic heart disease. 3 Patients with acute hemorrhagic shock. 4 Patients with chronic hemolytic Anemia 5 Patients who had previous adverse reaction to transfusion. 6 Patients with hematological and solid organ malignancy. 7 Patients who received transfusion within 48 hours before enrolling in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day MortalityTimepoint: 28th day after randomization | — |
Secondary
| Measure | Time frame |
|---|---|
| 28 day Ventilator Free daysTimepoint: 28th day after randomization;Daily Oxygenation index/Oxygen saturation indexTimepoint: During hospital stay;Daily PELOD scoresTimepoint: During hospital stay;Incidence of new onset MODS/ progression of MODSTimepoint: After first PRBC transfusion event;Length of Hospital stayTimepoint: During hospital stay;Length of PICU stayTimepoint: During hospital stay;Number of Adverse Events following PRBC transfusionTimepoint: During hospital stay | — |
Countries
India
Contacts
Public ContactJayashree M
PGIMER, Chandigarh
Outcome results
None listed