Health Condition 1: null- Cerebello-pontine angle tumour patients
Conditions
Interventions
Intervention1: Dexmedetomidine
Propofol
Fentanyl: Intraoperative continuous infusion of Dexmedetomidine (0.5 micgm/kg/hr) + Fentanyl (0.5 micgm/kg/hr) + Propofol (via Target Controlled Infusion - Schnider model - titrated to maintain Bispec
Fentanyl: Intraoperative continuous infusion of Fentanyl (0.5 micgm/kg/hr) + Propofol (via Target Controlled Infusion - Schnider model - titrated to maintain Bispectral Index between 40 - 60)
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing Cerebello-pontine angle surgeries with cranial nerve monitoring.
Exclusion criteria
Exclusion criteria: 1) Patients with evidence of sino-atrial nodal or atrio-ventricular nodal bradyarrhythmia on ECG, baseline heart rate 2) Patients with known history of hypertension and being treated with anti-hypertensive drugs. 3) Patients on tricyclic antidepressant, clonidine, monoamine oxidase-inhibitor therapy. 4) Patients with evidence of impaired hepatic/renal function according to past history or preoperative biochemistry parameters. 5) Need for intraoperative inotrope/vasopressor drug. 6) Allergy to egg/propofol 7) Absence of cranial nerve monitoring during surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of anaesthetic and analgesic sparing effect of dexmedetomidine.Timepoint: End of anaesthesia. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Recovery from anaesthesia based on time to opening eyes, time to following commands and time to extubation after anaesthetic withdrawal. 2) Evaluate the effect propofol alone and propofol-dexmedetomidine combination on acid base status. 3) Observe the incidence of adverse haemodynamic events. 4) Observe the effect of these two anaesthetic techniques on postoperative sedation, nausea and vomiting, shivering and pain scores. Timepoint: End of anaesthesia. | — |
Countries
India
Contacts
Public ContactKR Madhusudan Reddy
National Insitute of Mental Health and Neuro Sciences
Outcome results
None listed