Comparison of two anesthestic agents in irreversible pulpitis cases of upper first molar.

comparative evaluation of anesthetic efficacy of 4% articaine and 2% lidocaine for buccal infiltration in adult patients with irreversible pulpitis of maxillary first molar: A prospective randomized study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2016/12/007610

Enrollment

200

Registered

2016-12-23

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Irreversible Pulpitis

Interventions

Intervention1: Articaine: 4% Articaine 1:100,000 0.8ml Buccal infiltration Given once Pain Score observed after 7 minutes Control Intervention1: Lidocaine: 2% Lidocaine 1:100,000 1.6ml Buccal infiltra

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients having Moderate to severe pain in maxillary 1st molar tooth along with a positive response to cold testing with an ice stick & an electric pulp tester. 2. The ability of the patient to understand the use of pain scales. 3. The patient should be in good health & none should take any medication that would alter pain perception, as determined by oral & written questionnaire in last 24 hrs. 4. Absence of any periapical radiolucency on radiographs except for a widened periodontal ligament

Exclusion criteria

Exclusion criteria: 1. Patients with systemic disorder like diabetes, hypertension, asthma etc. 2. Patient having active pain in more than one maxillary molar in same quadrant. 3. Subjects taking any pain relieving medication including analgesics within last 24 hrs. 4. Subjects taking any antibiotics within 4 weeks before enrolment in the study. 5. Swelling associated with the tooth in question.

Design outcomes

Primary

Measure	Time frame
1. Both male and female patients experienced significantly less pain in Articaine group as compared to Lidocaine group. 2. the anesthetic efficacy of 2% Lidocaine is less as compared to 4% Articaine. 3. The anesthetic efficacy of buccal infiltration using 4% articaine is comparable with 2% Lidocaine but 4% Articaine has been found to be better than 2% Lidocaine because only 0.8 ml of 4% Articaine was injected as opposed to 1.6 ml of 2% Lidocaine. Timepoint: Initial pain and pain after 7 minutes of injection	—

Measure

Time frame

1. Both male and female patients experienced significantly less pain in Articaine group as compared to Lidocaine group. 2. the anesthetic efficacy of 2% Lidocaine is less as compared to 4% Articaine. 3. The anesthetic efficacy of buccal infiltration using 4% articaine is comparable with 2% Lidocaine but 4% Articaine has been found to be better than 2% Lidocaine because only 0.8 ml of 4% Articaine was injected as opposed to 1.6 ml of 2% Lidocaine. Timepoint: Initial pain and pain after 7 minutes of injection

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Secondary

Measure	Time frame
1. In all the failed cases in both the groups, patients had moderate to severe pain while inserting the file in palatal canals only. 2. In failed cases of both the groups female patients experienced more pain as compared to the male patients, however, it is not statistically significant in Articaine group but it is significant in Lidocaine group.Timepoint: Initial pain and pain after 7 minutes of injection	—

Measure

Time frame

1. In all the failed cases in both the groups, patients had moderate to severe pain while inserting the file in palatal canals only. 2. In failed cases of both the groups female patients experienced more pain as compared to the male patients, however, it is not statistically significant in Articaine group but it is significant in Lidocaine group.Timepoint: Initial pain and pain after 7 minutes of injection

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Countries

India

Contacts

Public ContactSyed Gufaran Ali

DY Patil Dental College Pune

sanjyotmulay@yahoo.co.in9822036048

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026