Comparison of three different antibiotics in treatment of urinary tract infection

Comparative Studies of Cotrimazole versus Norfloxacin versus Levofloxacin in Uncomplicated Cases of Lower Urinary Tract Infection in Adults Patients at Tertiary Care Hospital: A Randomize Controlled Parallel Group Open Label Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2016/12/007582

Enrollment

150

Registered

2016-12-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Uncomplicated Cases of Lower Urinary Tract Infection

Interventions

Intervention1: Norfloxacin 400 mg 12 hourly: orally for 3 days Intervention2: Levofloxacin 500 mg 24 hourly: orally for 3 days Control Intervention1: Cotrimoxazole 960 mg 12 hourly: orally for 3 days

Eligibility

Inclusion criteria

Inclusion criteria: Patients of lower UTI who are willing to take part in the proposed study Age > 18 & Subjects of newly diagnosed & conformed cases of lower UTI (Symptoms of dysuria or frequency/urgency of micturation) Female with child bearing age and not willing to conceive Normal laboratory parameters tested at screening to be in the range Normal liver function test (AST, ALT, Serum Total Bilirubin) Normal renal function test (Serum creatinin, Serum potassium) Hemoglobin at least 8 gm/dl or higher Negative pregnancy test (urine anti HCG antibody) in case of female patients Normal RBS

Exclusion criteria

Exclusion criteria: Subject with lower UTI along with upper UTI (Pain at renal angle (Flank pain)) Subject with BPH Intermittent perineal-low back pain, obstructive voiding symptoms (Prostitis) If subject neither has bacterial growth in culture nor has any episode of chronic prostitis Patient of recurrent urinary tract infection or of renal calculi Patient with urethral discharge Pregnancy Patient with diabetes Past history of renal disease Patient with any ECG abnormalities Subjects with urethral discharge Patient on immunosuppressive/steroids therapy Current antibiotic therapy within previous 15 days Unability to understand trial information Known resistant cases against study drug

Design outcomes

Primary

Measure	Time frame
To assess efficacy of Cotrimazole, Norfloxacin, Levofloxacin oral tablet in treating urinary tract infection Timepoint: At onset and 3 days of treatment Completion	—

Secondary

Measure	Time frame
To assess resistance and safety of Cotrimazole, Norfloxacin, Levofloxacin oral tablet in treating urinary tract infection Timepoint: At onset and 3 days of treatment Completion	—

Countries

India

Contacts

Public ContactDr Arpit Vachhani

Government Medical College, Bhavnagar, India

cbrtripathi@yahoo.co.in9825951678

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026