Health Condition 1: null- Advanced cancer Patients referred to palliative care
Conditions
Interventions
Intervention1: Dexamethasone: Dexmethasone 4 mg OD PO for 21 days
Control Intervention1: Megestrol Acetate: Megestrol acetate 40 mg QID PO for 21 days
Sponsors
Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1)Patient with clinical diagnosis of advanced cancer 2)Patients with ECOG 3)History of weight loss of more than 5% in the last 6 months(excluding perioperative weight loss) 4)Age over 18 years 5)Patients with physical symptoms like pain, breathlessness, nausea or vomiting , constipation or diarrhea, anxiety, depression scoring 6)Patient consenting and willing to participate in the study
Exclusion criteria
Exclusion criteria: 1)Patients with HIV AIDS/ End stage heart failure(LVEF 2)Patients with evidence of brain metastases or thromboembolic disorder within the previous 6 months 3)Patients on oral metronomic chemotherapy or on NSAIDs/ cox-2 inhibitors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| improvement in appetiteTimepoint: 3 weeks and 5 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect on Lean body weightTimepoint: 5 weeks;Effect on Quality of lifeTimepoint: 3 weeks and 5 weeks | — |
Countries
India
Contacts
Public ContactDr Shrenik Ostwal
Tata Memorial Hospital
Outcome results
None listed