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to study intraperitoneal use of clonidine(alpha agonist), as additive to local anaesthetic) for postoperative pain relief and sideeffects after abdominal uterus removal

Postoperative analgesic effect of intravenous (i.v.) clonidine compared with clonidine administration in wound infiltration for total abdominal hysterectomy â?? a randomized control study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/12/007544
Enrollment
60
Registered
2016-12-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA I & II patients aged 35 to 60 yrs for elective total abdominal hysterectomy after ruling out use of adrenoreceptor agonists,antagonists or narcotics before surgery, hypersensitivity to study drug. Health Condition 2: N998- Other intraoperative and postprocedural complications and disorders of genitourinary system

Interventions

Intervention1: intraperitoneal Clonidine: Clonidine given intraperitonealy at the dose of 3mcq/kg along with 30 ml of 0.25% Bupivicaine before peritoneal closure Control Intervention1: intravenous clo

Sponsors

Mata Chanan Devi Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: •60 ASA grade I and II female patients •Age between 35 to 60 years •scheduled for elective total abdominal hysterectomy surgery under general anaesthesia. •Patient willing to give written informed consent for participation in the study.

Exclusion criteria

Exclusion criteria: 1) Patients with â?? ASA grade 3 or above. 2) Age more than 60 yrs or less than 35 yrs. 3) Patients with morbid obesity, Raynaudâ??s disease. 4) Patients receiving adrenoreceptor agonists,antagonists, or narcotics before operation. 5) Patientâ??s refusal to participate in the study. 6) Known hypersensitivity to the study drug 7) H/o cardiovascular, respiratory, hepatic, renal, neurological or endocrine disease

Design outcomes

Primary

MeasureTime frame
To determine the analgesic efficacy of clonidine in wound infiltration with bupivacaine and to compare the same with Intravenous administration in terms of postoperative analgesic requirement and side-effects (nausea, sedation, bradycardia and hypotension)Timepoint: for heart rate and blood pressure- at peritoneal closure, 15,30,45,60,90,120 minutes after it. for pain,sedation,nausea- at post anaesthesia care unit arrival,2,4,6,12,24hours after it—

Secondary

MeasureTime frame
Dose of opioid neededTimepoint: over first 24 hours.;Time of opioid requirementTimepoint: noted for first 24 hours postoperatively.—

Countries

India

Contacts

Public ContactDivya Gupta

Mata Chanan Devi Hospital

drpmangwana@yahoo.com9810956411

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026