Health Condition 1: null- Spinal Anaesthesia induced Hypotension in Elective caesarean section
Conditions
Interventions
Intervention1: Group Norepinephrine: On development of hypotension, a predetermined dose of norepinephrine will be administered and response seen. The dose for each patient will be decided according t
Sponsors
University College of Medical Sciences and Guru Teg Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Healthy females with term, uncomplicated, singleton pregnancy undergoing elective caesarean section under spinal anaesthesia
Exclusion criteria
Exclusion criteria: Maternal complications e.g. diabetes, pre-eclampsia, other cardiovascular disease, cerebrovascular disease; multiple gestation; known fetal abnormality; patients with absolute or relative contra-indications for spinal anaesthesia e.g. infection in lumbar area, coagulation abnormalities, autonomic neuropathy, spinal deformities, other neurological diseases; hypovolemia due to any cause; maternal baseline SBP less than 100 mmHg; patients on monoamine oxidase inhibitors or tricyclic antidepressants; presence of mesenteric or peripheral vascular thrombosis
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| To determine potency ratio of norepinephrine and phenylephrine, administered as bolus for treatment of post-spinal hypotension during elective caesarean section, by calculating the ratio between ED50 of norepinephrine and phenylephrine.Timepoint: One minute after injection of vasopressor drug | — |
Primary
| Measure | Time frame |
|---|---|
| To determine potency ratio of norepinephrine and phenylephrine, administered as bolus for treatment of post-spinal hypotension during elective caesarean section, by calculating the ratio between ED95 of norepinephrine and phenylephrineTimepoint: One minute after injection of vasopressor drug | — |
Countries
India
Contacts
Public ContactDr Medha Mohta
University College of Medical Sciences and Guru Teg Bahadur Hospital
Outcome results
None listed