Health Condition 1: null- Recurrent Acute Pancreatitis
Conditions
Interventions
Intervention1: Antioxidants: The antioxidant supplementation (cocktail of 5 antioxidants) will include daily doses of 600 microgram organic selenium, 0.54 g vitamin C, 9000 IU beta-carotene, 270 IU vi
Sponsors
ICMRapplying for funding
Eligibility
Inclusion criteria
Inclusion criteria: Patients with recurrent acute pancreatitis
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating mothers 2. Who are already on anti-oxidants in previous month 3. Patients with AP or CP or complications of it 4. Patients with co-morbid diseases such as liver disease, chronic renal failure, malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The assessment of pain will be done in terms of total attacks of pancreatitis, requirement of oral and parenteral analgesics in the last six months and the need for hospitalisations in the previous 6 months. Pain score will be calculated with visual analogue scale (VAS).Timepoint: The assessment of pain will be done in terms of total attacks of pancreatitis, requirement of oral and parenteral analgesics in the last six months and the need for hospitalisations in the previous 6 months. Pain score will be calculated with visual analogue scale (VAS). Time Points: All the above parameters will be done at baseline, 3 months, 6months, 12 months and 18 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| The markers of oxidative stress estimated in the present study will be malondialdehyde (MDA), 4-hydroxynonenal (4HNE) and serum Superoxide Dismutase (SOD). The markers of antioxidant status assessed will be glutathione peroxidase (Gpx), total antioxidant capacity (measured as ferric reducing ability of plasma- FRAP) and levels of Vitamin C. Fecal samples will be collected for analysis of Elastase (ELISA kit) and serum c-peptide, fasting/ PP glucose and insulin levels will be seen.Timepoint: Time Point: All the above parameters will be done at baseline, 3 months, 6 months, 12 months and 18 months. | — |
Countries
India
Contacts
Public ContactAnoop Saraya
AIIMS, New Delhi
Outcome results
None listed