Health Condition 1: null- Histologically proven cases of Diffuse large B cell Non hodgkins lymphoma
Conditions
Interventions
Intervention1: Radiation Therapy: standard arm 45Gy in 25 fractions
Control Intervention1: Radiation Therapy: Experimental Arm 36Gy in 20 fractions
Sponsors
Tata Memorial Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1.Histological diagnosis of NHL-Diffuse laarge B cell lymphoma 2.Eligible for RT after R-CHOP chemotherapy regimen 3. ECOG 0-3 4. 18-59 YEARS 5. STAGE I-IV 6. Patient should receive atleast 4 cycles of R-CHOP chemotherapy 7. Patients with extranodal disease except one mentioned in the exclusion criteria 8. Able to understand and willing to provide informed consent for participation in the trial.
Exclusion criteria
Exclusion criteria: 1. HIV positive status 2.Relapse or progression of disease during chemotherapy 3. Prior history of chemotherapy 4. Systemic lymphomas with cns involvement 5. Primary extranodal testicular lymphomas 6. Primary extranodal CNS Lymphomas 7. Primary extranodal Stomach DLBCL 8. primary extranodal intestinal lymphoma 9. patient with >3 extranodal sites
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Event Free SurvivalTimepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Late ToxicityTimepoint: 2 years;Acute toxicityTimepoint: during radiation and upto 6 weeks after completion of RT;Local control ratesTimepoint: 2 years;Overall Response RateTimepoint: 3 months;Overall SurvivalTimepoint: 2 years;Quality Of Life scoresTimepoint: 2 years | — |
Countries
India
Contacts
Public ContactDr Jayant S Goda
Tata Memorial Centre
Outcome results
None listed