None listed
Conditions
Interventions
Intervention1: Moderate and high severe stress level people: Moderate and high severe stress level people will be analyzed for their hepatic CYP3A4 Metabolizing capacity by using probe drug Alprazolam
Sponsors
JSS University facility
Abhilash Thomas
Eligibility
Inclusion criteria
Inclusion criteria: age 20 to 60 both sexes Normal body mass index Normal waist hip ratio Subjects who did not consult any doctor for Stress relief treatment either pharmacological (drug therapy) or non pharmacological treatments like Yoga meditation etc
Exclusion criteria
Exclusion criteria: Subjects who are on renal or hepatic impairment Subjects who are on treatment for any kind of disease or disorders including Steroid therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome will be how different Stressors induces human body physiological functional changes leading to Hepatic CYP3A4 DYSREGULATION. If happens so the study drug to its metabolite ratio will be altered at every time pointsTimepoint: Within March of 2015 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The results obtained by using Probe drug can be extrapolated to any substrate drug. 2. Changes in the Pharmacokinetic parameters of the substrate drug (e.g. Amlodipine) shall be measured in a particular non hospitalized patient to optimize the desired Pharmacokinetics for the better therapeutic outcome.Timepoint: within September of 2015 | — |
Countries
India
Contacts
Public ContactAbhilash Thomas
JSS College of Pharmacy
Outcome results
None listed