FindTrial
Sign In

Does a drug dexmedetomidine have any effect on pressure on the brain which normally increases after introduction of gas in abdomen during laparoscopic surgery.

Effect of dexmedetomidine on increase in intracranial pressure caused by pneumoperitoneum which can be measured by optic nerve sheath diameter in adults during laparoscopic surgeries - a placebo controlled double blind RCT.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/11/007436
Enrollment
60
Registered
2016-11-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: addition of dexmedetomidine infusion during laparoscopic surgeries.: We wish to study the effect of dexmedetomidine infusion at a rate of 4 microgram per kg per minute starting 15 minut

Sponsors

AIIMS Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 and 2 patients undergoing elective laparoscopic surgery.

Exclusion criteria

Exclusion criteria: • History of any intracranial pathology • Patients with history of left ventricular failure, atrioventricular conduction block or any cardiac disease • Any intraocular/ophthalmic pathology • Patients with history of uncontrolled hypertension or diabetes. • Patients with renal and hepatic derangements • Patients taking clonidine, beta blocking drugs, calcium channel blockers, MAO inhibitors • Pregnant & lactating women • History of allergy to α2 agonist

Design outcomes

Primary

MeasureTime frame
1. to assess the change in optic nerve sheath diameter after pneumoperitoneum in the presence and absence of dexmedetomidine infusion.Timepoint: to assess the change in optic nerve sheath diameter 5 minutes after induction of anesthesia, 5 minutes after pneumoperitoneum, 5 minutes after patient position change and 5 minutes after desufflation.—

Secondary

MeasureTime frame
We wish to see if dexmedetomidine causes changes in intracranial pressure caused by change in positioning after pneumoperitoneum.Timepoint: 5 minutes after position change once pneumoperitoneum has been established.—

Countries

India

Contacts

Public ContactNishant Sahay

All India Institute of Medical Sciences, Patna

nishantsahay@gmail.com9431184516

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026