Health Condition 1: null- Breast Cancer
Conditions
Interventions
Intervention1: Basic Research: Paired tumor and blood samples from Breast cancer patients will be collected at the time of accrual and at first and subsequent progression.
Sponsors
SCIENCE ENGINEERING RESEARCH BOARD
Eligibility
Inclusion criteria
Inclusion criteria: Patients just diagnosed with recurrent/metastatic breast cancer after a previous diagnosis and treatment of non-metastatic breast cancer OR de nevo metastatic breast cancer Patients whose primary tumors are stored in the Tumor Tissue Repository of Tata Memorial Hospital in liquid nitrogen Patients willing to provide written informed consent to participate in the study including biopsies from recurrent/metastatic sites and longitudinal follow-up in their metastatic course Patients in whom biopsy from recurrent/metastatic sites can be performed with reasonable safety Patients whose tumors are triple negative by IHC (ER-/PR-/HER2-) Patients willing to receive the usual standard treatment for metastatic breast cancer
Exclusion criteria
Exclusion criteria: No exclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare sequential biopsies obtained at successive transition points to determine the impact of progression of the disease and treatment on tumor heterogeneity To determine whether breast cancer progression is parallel or sequential To determine the role of/ degree of clonal selection during the various transitions through defined clinical stages from primary tumor to end stage disease Identify novel targets and assess their role as drivers in the progression of the disease Timepoint: Patients with Triple negative breast cancer detected with newly developed metastatic breast cancer after a previous diagnosis and treatment of non-metastatic breast cancer (whose primary tumors are archived in the TMH Tumor Tissue Repository) OR de nevo metastatic breast cancer | — |
Secondary
| Measure | Time frame |
|---|---|
| NilTimepoint: Nil | — |
Countries
India
Contacts
Public ContactYogesh Kembhavi
Tata Memorial Centre
Outcome results
None listed