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A study to know the effect of Simvastatin gel on bone formation

Effect of in-situ application of Simvastatin gel in the surgical management of osseous defects in Chronic periodontitis- A clinico-radiographic study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/11/007428
Enrollment
20
Registered
2016-11-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients suffering from Chronic Periodontitis

Interventions

Intervention1: Group A was the treatment group: 20 patients contributing 40 sites (Split mouth) were recruited for study from the OPD of Department of Periodontics, K.L.E Societys institute of Dental

Sponsors

KLE Society Institute of Dental Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • Systemically healthy patient diagnosed with generalised chronic periodontitis • Clinical probing pocket depth >= 5 mm. • Radiographic evidence of bilateral intrabony defects in mandibular molar region

Exclusion criteria

Exclusion criteria: - History of antibiotics in last 6 months - History of periodontal therapy in last 6 months - Suspected allergy to statin group - Patients on systemic statin therapy - Patients having Aggressive periodontitis - Current smokers - Immunocompromised patient - Pregnant and lactating females - Patients having any bleeding disorders - Any other contraindication for periodontal surgery - Patients indicated for multiple extractions/undergone multiple extractions

Design outcomes

Primary

MeasureTime frame
Amount of bone fill and percentage of original defect fill in Group 1 was statistically highly significant than Group 2 at the end of 6 and 9 months.Timepoint: 3 months, 6 months and 9 months.

Secondary

MeasureTime frame
Both group resulted in significant improvement of both clinical and radiological parameters. There was significant reduction of Gingival Index (GI) , Probing pocket Depth (PPD) and gain in Clinical attachment level (CAL) was observed at the end of 3.6 and 9 months.Timepoint: 3 months, 6 months and 9 months

Countries

India

Contacts

Public ContactDr Rajeev Ranjan

K.L.E Societys Institute of Dental Sciences

zonaperio@gmail.com9845560110

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026