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Metformin in mild asymptomatic hypothyroidism

Effect of Metformin on Thyroid Function Test in Patients with Subclinical Hypothyroidism - An Open Label Randomized Control Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/11/007426
Enrollment
60
Registered
2016-11-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Subclinical Hypothyroidism

Interventions

Intervention1: Metformin Arm: Metformin 500 mg three times a day for 6 months Control Intervention1: Control Arm: nil

Sponsors

JIPMER Intramural fund
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Newly diagnosed patients with subclinical hypothyroidism with Serum TSH: 5.5-10 mIU/L

Exclusion criteria

Exclusion criteria: 1.Patients with diabetes mellitus 2.Symptomatic subclinical hypothyroidism 3.Patients who have received metformin, and other medications like cimetidine, phenytoin, cholestyramine, and cyclosporine or drugs known to affect thyroid function 4.Pregnant or lactating women or patients of infertility 5.Chronic illness like chronic kidney disease, liver disease,anaemia 6.BMI 35 7.Patients with dyslipidemia

Design outcomes

Primary

MeasureTime frame
TSH, fT4, fT3Timepoint: at baseline, 3 months and 6 months after intervention—

Secondary

MeasureTime frame
serum leptin and adiponectin level Insulin resistanceTimepoint: baseline and at 6 months after intervention—

Countries

India

Contacts

Public ContactDr Jayaprakash Sahoo

Jawaharlal Institute of Postgraduate Medical Education and Research

sadishkk@gmail.com9629528518

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026