Health Condition 1: null- Patients Undergoing Epilepsy Surgery
Conditions
Interventions
Intervention1: Dexmedetomidine: Drug will be given as intravenous infusion in intraoperative period
Control Intervention1: Normal saline: Drug will be given as intravenous infusion in intraoperative p
Sponsors
ALL INDIA INSTITUTE OF MEDICAL SCIENCES
Eligibility
Inclusion criteria
Inclusion criteria: 1.Consenting patients 2.Intractable epilepsy posted for epilepsy surgery under general anesthesia being operated by single neurosurgeon (PSC) 3.ASA grade I & II
Exclusion criteria
Exclusion criteria: 1.Non consenting patients 2.Known hypersensitivity to dexmedetomedine 3.Patients with heart block 4.Patients with hypotension 5.Pregnant patients 6.Patients with renal/hepatic disease 7.Patients on beta blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ï?·To study the effect of dexmedetomidine and placebo on cerebral injury markers(S100B & NSE) in patients undergoing epilepsy surgeryTimepoint: 1.Preoperative 2.Postoperative 3.24 hours 4.48 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| ï?·To find relation between s100b and NSE in the postoperative period ï?·To find relation between seizure control with markers of cerebral ischemia ï?·To find relationship between use of dexmedetomidine and postoperative seizure controlTimepoint: Preoperative period Immediate Postoperative 24 Hours Postoperative AT TIME OF DISCHARGE | — |
Countries
India
Contacts
Public ContactDr Ashish Bindra
All India Institute Of Medical Sciences
Outcome results
None listed