Comparison of the efficacy of two dosing regimens of Vitamin D for bone protection in children with difficult nephrotic syndrome

Comparison of the efficacy of two dosing regimens of Vitamin D supplementation for osteoprotection in children with difficult nephrotic syndrome: An open-label randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2016/10/007405

Enrollment

Registered

2016-10-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- having nephrotic syndrome

Interventions

Intervention1: Nephrotic syndrome group: In this two group are there group A receiving 1000 iu vit. D daily and group B receiving 400 iu daily, intervention done on both group as dexa scan, and blood

Eligibility

Inclusion criteria

Inclusion criteria: Children ( >1 year) with difficult nephrotic syndrome (FRNS, SDNS and SRNS), attending pediatric nephrology clinic and pediatric inpatient department, JIPMER

Exclusion criteria

Exclusion criteria: i)Children with history of hypocalcemic seizures, tetany, rickets or fractures. ii)Known cases of renal stones. iii)Children on phenytoin, phenobarbitone, methotrexate, furosemide, thiazides or bisphosphonates. iv)Chronic renal failure or chronic liver disease. v)Secondary causes of NS (e. g IgA nephropathy, Henoch Schonlein Purpura nephritis, Lupus nephritis) vi)Children already taking vitamin D.

Design outcomes

Primary

Measure	Time frame
change in Bone Mineral Content (BMC) in children with difficult nephrotic syndrome treated with 400 IU per day versus 1000 IU per day of Vitamin D supplementation during a one-year follow up periodTimepoint: 12 months	—

Secondary

Measure	Time frame
Secondary outcome variables (BMD, serum calcium, phosphate, alkaline phosphatase, iPTH)Timepoint: 12 months	—

Countries

India

Contacts

Public ContactDr Sriram Krishnamurthy

JIPMER Puducherry

dhurvasingh33@gmail.com9843397648

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026