Health Condition 1: null- Type 2 diabetes mellitus patients Health Condition 2: E119- Type 2 diabetes mellitus without complications
Conditions
Interventions
Intervention1: Curcuma longa capsules: Curcuma longa capsules 400mg tds for 3 months in addition to standard background therapy(metformin with or without sulfonylureas)
Control Intervention1: Placebo
Sponsors
JIPMER Intramural fund
Eligibility
Inclusion criteria
Inclusion criteria: Native Tamilian patients with type 2 diabetes mellitus diagnosed within the past 3 months to 10 years, on stable dose of metformin with or without sulfonylureas, for at least past 3 months
Exclusion criteria
Exclusion criteria: 1) Liver dysfunction (AST,ALT > 2 times the upper limit of normal) 2) Renal dysfunction (GFR 3) Patient with concurrent illnesses like CAD(Coronary Artery Disease), CVA( cerebrovascular accidents), PVD(Peripheral Vascular Disease), CKD( Chronic Kidney Disease)other than hypertension 4) Patients taking anti diabetic drugs other than metformin and sulfonylureas 5) Pregnant women or lactating mothers; women in reproductive age group not practicing contraceptive measures. 6) Patients who had participated in other trials in the past three months. 7) Those on other herbal medications. 8) Current smokers 9) alcoholics 10) Patients with active infections such as diabetic foot infection etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| carotid femoral pulse wave velocityTimepoint: baseline,1st,2nd,3rd month | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.arterial stiffness index, ankle brachial index, aortic systolic/diastolic pressures, augmentation pressure, augmentation index 2. ICAM and VCAM 3. adiponectin and leptin 4. the adverse drug reactions(ADR)to Curcuma longaTimepoint: 1.At baseline, At the end of 1st month, 2nd month and 3rd month 2.baseline and 3 months 3.baseline and 3 months 4.1st,2nd and 3rd month | — |
Countries
India
Contacts
Public ContactDr Sandhiya S
JIPMER
Outcome results
None listed