Health Condition 1: null- Acute exacerbation of Bronchial Asthma
Conditions
Interventions
Intervention1: Montelukast: Patients in the montelukast arm will be given oral Montelukast 10 mg tablet at enrollment and a placebo tablet after 12 hours,in addition to the standard treatment for asth
Sponsors
Dr vyshak U S
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 65. 2.Previously diagnosed case of bronchial asthma. 3.A primary diagnosis of acute exacerbation of asthma on presentation. 4.Peak expiratory flow rate (PEFR)less than or equal to 75% of personal best with in the last 12 months or of predicted value. 5.No other acute pathology complicating the present condition like cardiac,metabolic or other respiratory causes.
Exclusion criteria
Exclusion criteria: 1.Smoking history more than 10 pack years. 2.Pregnant females and Breast feeding females. 3.Patient on regular Leukotriene receptor antagonists or thromboxane A2 synthetase inhibitor with in 2 weeks of presentation. 4.Intake of oral or parenteral steroids for > 5 days with in one month of presentation. 5.Intake of theophylline with in one week of presentation. 6.Need of intubation before presentation. 7.Patients on regular Rifampicin, Phenytoin or Phenobarbitone. 8. History of allergy to Montelukast or ozagrel. 9. Baseline renal function test and liver function test derangement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage change in PEFR (Peak expiratory flow rate)from baseline.Timepoint: 6 hrs 12 hrs 24 hrs and 48 hrs following administration of study drug and at discharge. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of times rescue medications were required.Timepoint: Any time from the administration of study drug to the time of discharge. | — |
Countries
India
Contacts
Public ContactDr Rahul Magazine
kasturba medical college manipal
Outcome results
None listed