Health Condition 1: null- Aneurysmal subarachnoid haemorrhage
Conditions
Interventions
Intervention1: Tab Pregabalin: Tab Pregabalin 75 mg bid from admission to 24 hours after surgery
Control Intervention1: Pregabalin Placebo: blank pregabalin capsules with active ingredient removed.
Sponsors
Sree Chitra Tirunal Institute of Medical Sciences and Technology
Eligibility
Inclusion criteria
Inclusion criteria: Sub arachnoid haemorrhage as evidenced by CT, CT Angiography, DSA, MR Angiogram Symptomatic headache Able to swallow oral medication Able to verbalize pain score Time period between the time of aneurysm bleed to enrolment into the study should be less than three days
Exclusion criteria
Exclusion criteria: Being on pregabalin or gabapentin derivatives in the past two weeks Pregnancy / Lactation Renal failure (Se Creat >1.4mg%) Patients with chronic pain syndromes on chronic pain medication SAH grading - WFNS grade 3, 4 & 5 ASA (American Society of Anaesthesiology) 3,4 and 5 Known allergy to Tab Paracetamol or Tab Pregabalin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fentanyl in mcg/kg (above the baseline infusion)Timepoint: at the end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scoreTimepoint: pre-induction for surgery;Visual analogue score for painTimepoint: 6, 12 and 24 hours post operation | — |
Countries
India
Contacts
Public ContactDr Karen Ruby Lionel
Sree Chitra Tirunal Institute of Medical Sciences and Technology
Outcome results
None listed