Health Condition 1: null- Acute Deep Vein Thrombosis
Conditions
Interventions
Intervention1: 10mg oral dose initiation nomogram: All patients in this arm will receive 10mg warfarin on day 1 and day 2 and dosage will be adjusted based on INR value from day 3 until a primary or s
Sponsors
Fluid Research Grant Christian Medical College Vellore
Eligibility
Inclusion criteria
Inclusion criteria: All patients, 18 years or older, with acute deep vein thrombosis being started on oral anticoagulation therapy by the division of surgery who consent to participation in the trial
Exclusion criteria
Exclusion criteria: 1. Weight 2. Underlying liver, renal disease 3. Recent treatment with any anticoagulants (within the preceding 5 days), Baseline INR >1.4 4. Pre-existing bleeding diatheses. 5. Diagnosed pulmonary embolism 6. Special patients eg pregnancy, children 7. Non consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to therapeutic INR (confirmed by two consecutive readings of between 2 to 3 at least 24 hours apart)Timepoint: Daily INR will be checked from day 3 onwards | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding or over-anticoagulation(INR8.0)Timepoint: any point during study;DeathTimepoint: any point during study;Failure to anticoagulate (Failure to achieve adequate anticoagulation despite maximum possible trial dose for three consecutive days)Timepoint: Day 5 onwards | — |
Countries
India
Contacts
Public ContactSrujan Lam Sharma
Christian Medical College, Vellore
Outcome results
None listed