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Pain relieving strategies in chronic tension-type headache(CTTH)

Effect of rTMS on central and peripheral pain modulation in chronic tension-type headache

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/10/007344
Enrollment
20
Registered
2016-10-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- chronic tension type headache

Interventions

Intervention1: 1. Sucrose challenge test 2. Repetitive transcranial magnetic stimulation(rTMS): 1. Sucrose 25 gm/100ml orally pre and post rTMS (4 weeks)
2. Non invasive transcranial magnetic stimulation 1.0Hz for 30min/day for five consecutive days/week) for 4 weeks 3.Patient will be followed up for pain status and anxiety scores for 6 months Control
chronic tension type headache subjects: Normal healthy subjects and Chronic tension type headache subjects with age group between 18-50 years

Sponsors

AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: This study is a randomized, parallel group, placebo controlled trial to study the effect of transcranial magnetic stimulation on pain modulation status in chronic tension-type headache patients. Primary outcomes will be subjective and objectives assessment of pain, biochemical analysis before and after rTMS therapywhich will be given for four weeks/five consecutive days/week.

Exclusion criteria

Exclusion criteria: Use of morphinomimetic drugs,Use of muscle relaxants H/o drug addiction H/o Hormonal therapy H/o vasodilator drugs H/o other pain relieving measure like yoga, acupuncture, acupressure etc. H/o ferromagnetic implants in head and neck regions, cardiac pacemakers H/o abnormal menstrual cycle, pregnancy, lactation H/o seizure H/o diabetes H/o any peripheral neuropathy

Design outcomes

Primary

MeasureTime frame
1.Decrease in VAS Pain rating by 50% 2.Improvement decrease in LH level in response to sucrose challenge test which is deranged in CTTH patients 3.The improvement nociceptive flexion reflex/R-III thresholdTimepoint: The assessment will be done at the beginning of the treatment and after the completion of 20 days of rTMS therapy—

Secondary

MeasureTime frame
Pain in CTTH is mediated by opioids rTMS is effective therapy for treatment of CTTH Timepoint: Outcome name:Oral sucrose challenge test, 25gm/100 ml, pre and post rTMS, Time points:6 months, 1 year Outcome name: rTMS, 30 min/day/20 sessions, Time points:4 weeks—

Countries

India

Contacts

Public ContactDr Renu Bhatia

All India Institute of Medical Sciences

bhawnamattoo@gmail.com09717460911

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026