Health Condition 1: G978- Other intraoperative and postprocedural complications and disorders of nervous system
Conditions
Interventions
Intervention1: Fentanyl plus midazolam combination: Fentanyl plus midazolam combination will be given before etomidate administration
Control Intervention1: Fentanyl
Midazolam: Fentanyl will be given
Sponsors
Safdarjang Hospital
Eligibility
Inclusion criteria
Inclusion criteria: American Society of Anesthesiology physical status I and II adult patients Elective surgery requiring general anesthesia
Exclusion criteria
Exclusion criteria: Patients with allergy to benzodiazepines, opioids or etomidate, with neuropsychological illness, seizure disorder, sepsis, history of alcohol or drug abuse and those who have received analgesics or sedatives within the previous 24h;Patients on steroid medication, or those who have received steroids in the last 3 months and those with adrenocortical insufficiency; anticipated duration of surgery less than 30 minutes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the effect of pre-treatment with combination of midazolam and fentanyl with either drug used alone on the incidence and severity of etomidate induced myoclonus in adult patients undergoing elective surgery under general anesthesiaTimepoint: One minute after administration of etomidate | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To study the effect of pretreatment with midazolam, fentanyl and their combination on haemodynamic parameters. 2. To study the effect of pretreatment with midazolam, fentanyl and their combination on degree of sedation Timepoint: Haemodynamic parameters: Baseline, preinduction, postinduction,at 3 min post-induction, and at 1 min, 3 min and 5 min after intubation. Sedation: After 5 minutes of administration of study drugs (fentanyl and midazolam) | — |
Countries
India
Contacts
Public ContactSmita Prakash
Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India
Outcome results
None listed