Health Condition 1: null- Patient under going elective surgery in General Anaesthesia
Conditions
Interventions
Intervention1: Vecuronium: 0.8mg/kg Loading dose and 0.2 mg/kg maintanace dose
Control Intervention1: Ranitidine: 50 mg Intravenous, 24 hour before and just before surgery.
Control Intervention2: Pant
Sponsors
Government Medical College Department of Pharmacology
Eligibility
Inclusion criteria
Inclusion criteria: • Patient scheduled of elective surgery lasting >=60 minutes • American Society of Anaesthesiology [ASA] status I or II. • Patient is able to read and understand the information sheet and to sign and date the consent form. • Adult, age >=18 to 65 years, male or female
Exclusion criteria
Exclusion criteria: • Patient refusal • Absolute and relative contraindication to vecuronium • A history of allergy or hypersensitivity to succinylcholine • Electrolyte abnormalities (for instance, hypermagnesemia or hyperkalemia) • Hepatic dysfunction • Renal Dysfuncuion. • Any known drug which are having neuromuscular blockade
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of effect of pantoprazole and famotidine on neuromuscular blockade of vecuronium in terms of total duration of blockade.Timepoint: After giving general anaesthesia through out the operation peripheral nerve stimulator will placed and neuromuscular blockade will be measured. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of effect of pantoprazole and famotidine on neuromuscular blockade of vecuronium in terms of onset of blockade, recovery duration.Timepoint: evaluation of blockade and total duration of blockade starting from general anaesthesia to reversal of anaesthesia neuromuscular blockade will be measured by peripheral nerve stimulator and individual drug level in blood by HPLC. | — |
Countries
India
Contacts
Public ContactDr C B Tripathi
Government Medical College, Bhavnagar.
Outcome results
None listed