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A pilot study project to determine the expression of adrenergic receptors (ADRs) in the archival formalin-fixed, paraffin embedded (FFPE) tissue blocks of different subtypes of bone or soft tissue Sarcomas

A pilot project to determine the expression of adrenergic receptors (ADRs) in the archival formalin-fixed, paraffin embedded (FFPE) tissue blocks of different subtypes of bone or soft tissue Sarcomas- Feasibility study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2016/09/007264
Enrollment
100
Registered
2016-09-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Bone tumours or Soft Tissue Sarcomas

Interventions

Intervention1: Nil: NA Control Intervention1: Nil: NA

Sponsors

TMC Research and Administration Council
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Histopathological diagnosis of sarcoma including bone or soft tissue sarcomas. 2. Availability of archival tissue blocks in sufficient material to perform immunohistochemical staining and adrenergic receptor gene expression.

Exclusion criteria

Exclusion criteria: Inability to perform immunohistochemical staining and adrenergic receptor gene expression related to poor quality or insufficient quantity of archival tissue material.

Design outcomes

Primary

MeasureTime frame
Estimate tumoral expression of adrenergic receptors, beta2 adrenergic receptors (B2-ADR), phosphorylated beta2 adrenergic receptors (B2 ADRP), alpha1 adrenergic receptors (A1-ADR) and alpha2 adrenergic receptors (A2- ADR2) by immunohistochemical staining and beta-adrenergic receptor gene expression by conventional PCR among the different subtypes of sarcomasTimepoint: Slides provided at the time of tumour biopsies for diagnosis—

Secondary

MeasureTime frame
1) Correlation between the methods used for ADRs expression (immunohistochemical staining and receptor gene expression)Timepoint: Slides provided at the time of tumour biopsies for diagnosis—

Countries

India

Contacts

Public ContactDr Siddharth Turkar

Tata Memorial Hospital

banavali_2000@yahoo.com9820074514

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026