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Comparison of laser with topical medication in the treatment of melasma

A split face randomized control study comparing the efficacy and safety of 1064 nm Q-switched Nd-YAG laser in the treatment of melasma compared to topical modified Kligmanâ??s formulation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/09/007249
Enrollment
40
Registered
2016-09-07
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Melasma

Interventions

Intervention1: Q switched Nd YAG laser: Q switched Nd YAG laser on selected half of face (wave length 1064 nm, fluence 1. 5 J cm2, spot size 6 mm, frequency 10, number of passess 10, session frequency

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • Age group: 20- 40 years • Female patients with clinical diagnosis of melasma • Patients who have not received any prior medical treatment for melasma or with a wash out period of 4 weeks.

Exclusion criteria

Exclusion criteria: • Age group 40 years • Pregnant or lactating females • Patients on medications like oral contraceptives, hormone replacement therapy in the last three months • Patients with systemic or endocrinological disorder like thyroid disease

Design outcomes

Primary

MeasureTime frame
The number of patients who had complete or near complete clearance of pigmentation The rate at which pigment clearance occurs Melanin index MASI score Adverse reactions Duration of response Timepoint: During the treatment ( initial 12 weeks) all the parameters will be assessed weekly followed by monthly assessment during the follow-up period of 3 months

Secondary

MeasureTime frame
NoneTimepoint: None

Countries

India

Contacts

Public ContactDr Tanvi Dev

All India Institute of Medical Sciences (AIIMS)

aiimsgsr@gmail.com911126594369

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026