Health Condition 1: null- drug refractory epilepsy patient admitted in epilepsy monitoring unit
Conditions
Interventions
Intervention1: antiepileptic drugs: Rapid withdrawal of antiepileptic drugs: dose of drugs will be decreased daily by 30-50%.
Detail mentioned in protocol summary.
Control Intervention1: antiepileptic
Sponsors
Prof Manjari Tripathi
Eligibility
Inclusion criteria
Inclusion criteria: • Patients admitted in epilepsy monitoring unit (EMU) •Patient giving consent
Exclusion criteria
Exclusion criteria: •Patient not giving Consent. •Patients having history of status epilepticus and Seizure frequency more than 1/day •Patient with significant non- neurological co-morbidities like chronic cardiac, renal and other systemic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in the duration of long-term video-EEG completion time between rapid and slow AED taper groups.Timepoint: Time points will be calculated as total days patient admitted in epilepsy monitoring room. | — |
Secondary
| Measure | Time frame |
|---|---|
| long term video-EEG diagnostic yield (calculated as a percentage of prerecording question answered upon completion of LTM) in both groupsTimepoint: Time points will be calculated as total days patient admitted in epilepsy monitoring room.;The percentage of patient with ictal onset EEG localization in two groupsTimepoint: Time points will be calculated as total days patient admitted in epilepsy monitoring room.;The percentage of secondary GTCS (sGTCS), 4-hr and 24-hr cluster, status epilepticus, need for midazolam rescue treatment and LTM associated complications in two groupsTimepoint: Time points will be calculated as total days patient admitted in epilepsy monitoring room;The time to first seizure in two groupsTimepoint: Time points will be calculated as total days patient admitted in epilepsy monitoring room. | — |
Countries
India
Contacts
Public ContactProf Manjari Tripathi
All India Institute of Medical Sciences, new delhi
Outcome results
None listed