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comparison of various drugs used for sedation during surgery.

A comparison of infusions of propofol, midazolam and ketamine for conscious sedation during spinal anesthesia- a prospective randomized study.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/08/007197
Enrollment
150
Registered
2016-08-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA grade I & II

Interventions

Intervention1: Dr Varun Chauhan: Resident: will perform the spinal anesthesia and start sedative infusion. Intervention2: midazolam infusion: started at 0.5mg/kg/hr,titrated to a Ramsay sedation score

Sponsors

Department of Anaesthesiolgy
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 & 2 patients weighing 40 to 80 kilograms Scheduled for either elective lower limb or lower abdominal surgical procedures, which were anticipated to complete within 2 hours, were included.

Exclusion criteria

Exclusion criteria: 1.Patients with history of allergic reaction to the study drugs 2.those with significant cardiac , pulmonary, hepatic or renal dysfunction 3.Patients with history of psychiatric illness 4.Obese patients (BMI > 30 kg/m2) 5.Hypertensive patients 6.Patients with head injury 7.Those with history of chronic use of sedative drugs, full stomach patients, pregnant patients and epileptic patients were excluded from the study.

Design outcomes

Primary

MeasureTime frame
1.To study the duration of amnesia following the administration of the three amnestic agents. 2.To investigate duration and extend of retrograde amnesia and anterograde amnesia 3.To investigate the dose response relationship of amnesia with the various agents. Timepoint: 30 June 2016

Secondary

MeasureTime frame
1.To investigate the level of patient satisfaction with the sedative amnestic agent. 2.To investigate the time to recovery with equisedative doses of the various agents. 3.To investigate the incidence of untoward events with each agent 4.To determine strategies to reduce intraoperative awareness ( prevent explicit recall) Timepoint: post operative day 1

Countries

India

Contacts

Public ContactDr Varun Chauhan

Thesis guide

drmonikagandhi2911@gmail.com9302105470

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026