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A STUDY TO COMPARE THE EFFICACY OF INTRAVENOUS DEXMEDETOMIDINE AND CLONIDINE IN SUPRESSION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION

A RANDOMIZED CONTROLLED TRIAL TO COMPARE THE EFFICACY OF INTRAVENOUS DEXMEDETOMIDINE AND CLONIDINE AS ADJUVANTS TO LOW DOSE OPIOID IN ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/08/007191
Enrollment
120
Registered
2016-08-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA grade 1 & 2 patients posted for surgery under general anaesthesia

Interventions

Intervention1: Intravenous clonidine: Intravenous clonidine 1mcg/kg and intravenous Fentanyl 1 mcg/kg before induction of anaesthesia Intervention2: Intravenous Dexmedetomidine: Intravenous Dexmedetom

Sponsors

Lady Hardinge Medical College and Shrimati Sucheta Kriplani Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I &II, undergoing elective surgery under general anaesthesia with endotracheal intubation

Exclusion criteria

Exclusion criteria: • Anticipated Difficult intubation(MPG III/IV) • Emergency surgical procedure • BMI >30 • Patients with any systemic disease • Refusal by the patient • H/O allergy to any drug

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of intravenous dexmedetomidine & clonidine as adjuvants to low dose opioid (fentanyl) in attenuating the haemodynamic response to laryngoscopy and tracheal intubation in patients undergoing surgery under general anaesthesiaTimepoint: Heart rate and mean blood pressure were recorded as baseline(before study drug), after study drug at 5,10 & 15 mins, after I.V. induction, at intubation (0 min), 1, 3, 5, 10 and 15 mins after intubation—

Secondary

MeasureTime frame
1.To compare the dose requirement of opioid (fentanyl) and other anaesthetic agents (thiopentone) in all three groups. 2. To compare the duration of postoperative analgesia. 3. To look for side effects, if any. Timepoint: from the start of study drug upto the postoperative period—

Countries

India

Contacts

Public ContactNAVNEET GUPTA

Lady Hardinge Medical College and Shrimati Sucheta Kriplani Hospital

dr.ajaikumar11@gmail.com9868848814

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026