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The role of GnRH analogues (medical therapy) in improving fertility in women with early stage endometriosis.

The role of GnRH analogues in improving outcome in women undergoing super-ovulation and intra-uterine insemination after surgical correction of minimal to mild endometriosis: a randomised control trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/08/007162
Enrollment
90
Registered
2016-08-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- infertility due to endometriosis (minimal to mild)

Interventions

Intervention1: GnRH analogue after surgery for endometriosis: GnRH Analogue (injection leuprolide acetate 3.75mg s.c.) single dose, given to patient after surgical correction of endometriosis by lapar

Sponsors

AIIMS New Delhi
Lead Sponsor
Bharat Serums And Vaccines Limited
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Infertile women with minimal or mild endometriosis post laparoscopic surgical treatment. 2. Age less than or equal to 36 yrs. 3. Husband with normal semen parameters

Exclusion criteria

Exclusion criteria: 1. Age > 36 yrs. 2. Moderate or severe endometriosis. 3. Pelvic inflammatory disease including genital Tuberculosis. 4. Poly-Cystic Ovarian Syndrome (PCOS). 5. Endometrial polyp, Sub-mucous myoma. 6. Diminished ovarian reserve as evaluated with FSH >10 IU/ml. 7. Recurrent endometriosis. 8. Male factor infertility.

Design outcomes

Primary

MeasureTime frame
clinical pregnancy ratesTimepoint: Confirmation of clinical pregnancy was done by presence of a viable fetus at 6 weeks by ultrasonography—

Secondary

MeasureTime frame
days of stimulationTimepoint: day of administering hCG injection.;dose of gonadotropin injectionTimepoint: calculated using vials containing 150 IU of hMG per vial;Endometrial thicknessTimepoint: greater than or equal to 7mm.;number of folliclesTimepoint: follicle size greater than or equal to 18mm.—

Countries

India

Contacts

Public ContactDr Piyush Bansal

AIIMS, New Delhi

mahotraneena@yahoo.com9910281232

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026