Health Condition 1: null- Parkinsonism Health Condition 2: G20- Parkinsons disease
Conditions
Interventions
Intervention1: Memantine and levodopa: Add on memantine tablets 20 mg once daily orally for 1 year with levodopa tablets 125 mg once daily orally for one year.
Control Intervention1: levodopa: levodop
Sponsors
SRM University
Eligibility
Inclusion criteria
Inclusion criteria: 1)Patients diagnosed with idiopathic PD based on UKPDS Diagnostic Criteria diagnosed Fewer than 7 years 2)Patients Requiring dopaminergic anti-parkinsonism therapy 3)Patients willing to give informed consent
Exclusion criteria
Exclusion criteria: 1) Subjects who are currently treated with apomorphine and/or dopamine receptor antagonists 2) Subjects treated with anticholinergic medications or amantadine alone 3) severe dementia 4) Subjects who have undergone a neurosurgical procedure for PD 5) Subjects who have atypical parkinsonism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| improvement in parkinsonism and dyskinesias with quality of life assessed by UPDRS, DRS, MMSC, PD quality of life scalesTimepoint: at the end of each month for 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in Quality of Life improvement in memory functionsTimepoint: at the end of each month for 1 year | — |
Countries
India
Contacts
Public ContactDr Kabilan K
SRM University
Outcome results
None listed