To compare the responses of pulse rate and blood pressure for electroconvulsive therapy in general anesthesia when dexmedetomidine, lignocaine and esmolol are used.

A comparison of two doses of Dexmedetomidine, Esmolol and Lignocaine for the prevention of haemodynamic response to electroconvulsive therapy under general anaesthesia - DELECT

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2016/08/007125

Enrollment

Registered

2016-08-01

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- patients suffering from various psychiatric disorders for whom electroconvulsive therapy (ECT)is advised by the psychiatrist

Interventions

Intervention1: Dexmedetomidine 1microgram/kg: The patients will receive an intravenous infusion of Dexmedetomidine 1mcg/kg over 10 min followed by bolus of 10ml normal saline over 15 minutes before in

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA grade I/II 2.Patients of either sex. 3.Age between 18-60 years. 4.Patients undergoing ECT in general anaesthesia who advised atleast five ECTS . 5.Patients consenting for the study

Exclusion criteria

Exclusion criteria: 1.ASA grade III/IV 2.BMI >30 3.Known sensitivity to General Anaesthetic drugs. 4.Known allergy to study drugs. 5.Pregnant and lactating females. 6.Patients on beta blockers or calcium channel blockers. 7.Known Hypertensives on treatment. 8.Bronchospasm or bronchial asthma. 9.Systolic BP 10.Heart rate

Design outcomes

Primary

Measure	Time frame
To compare the effects of two doses of Dexmedetomidine(0.5 and 1mic), Esmolol and Lignocaine during Electroconvulsive therapy under general anaesthesia in terms of Intraoperative hemodynamics (heart rate, blood pressure, rate pressure product). Timepoint: at baseline, after study drug, after induction of anaesthesia, and at 1, 3, 10 minutes after ECT.	—

Secondary

Measure	Time frame
1.Duration of motor seizure. 2.Time to spontaneous breathing, eye opening and obeying commands. 3.Post-procedure sedation/agitation. 4.Readiness to discharge. 5.Propofol requirement. Timepoint: all this will be noted at the end of the ECT session upto discharge.	—

Countries

India

Contacts

Public ContactDevangi Parikh

LTMMC and LTMGH, Sion, Mumbai

sdevangi10@gmail.com9820471638

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026