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Effect of two commonly used intravenous fluids (Ringers lactate and tetrastarch) on postoperative kidney function

EARLY POSTOPERATIVE ACUTE KIDNEY INJURY: EFFECT OF INTRAOPERATIVE TETRASTARCH VERSUS RINGERâ??S LACTATE â?? A RANDOMISED CONTROLLED TRIAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/07/007114
Enrollment
32
Registered
2016-07-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: null- Adult patients scheduled for major orthopaedic surgery under general anaesthesia with anticipated blood loss greater than 200-300 ml will be included in the study.

Interventions

Intervention1: Tetrastarch group: Patients randomised to this group will receive intraoperative fluid therapy using tetra starch i.e., 6% HydroxyEthylStarch 130/0.4. Control Intervention1: Ringers La

Sponsors

University College of Medical Sciences and GTB Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients scheduled for major orthopaedic surgery under general anaesthesia with anticipated blood loss > 200-300 ml will be included in the study.

Exclusion criteria

Exclusion criteria: Those 65 years, body mass index 40 kg/m2, will not be included. Patients with preoperative renal dysfunction, receiving renal replacement therapy, transplanted kidney, significant dysrhythmia, cardiac failure, stroke, coronary heart disease with left ventricular ejection fraction <50%, or preoperative haemoglobin < 8 gm% will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
Early postoperative Acute Kidney Injury diagnosed by the levels of NGAL(Neutrophil gelatinise associated Lipocalcin) in urine.Timepoint: After completion of surgery and on first postoperative day.—

Secondary

MeasureTime frame
1. Early postoperative AKI diagnosed as per conventionally used definitions formulated by the Kidney Disease Initiative: Global Outcomes (KDIGO) guidelines, using serum creatinine and/or urine output. 2. Intraoperative haemodynamic stability: in terms of mean arterial pressure, cardiac index and stroke volume/SVV. Timepoint: 1. For early AKI: Serum creatinine will be done at 48 hours postoperatively. 2. For intraoperative haemodynamic stability the stated variables will be recorded every 10 minutes intraoperatively till end of surgery.—

Countries

India

Contacts

Public ContactGaurav Verma

Department of Anaesthesiology and Critical Care

gaurav63mamc@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026