Health Condition 1: null- Adult ASA Grade I or II patients of either sex, aged 18 to 60 years, who underwent elective laparoscopic surgeries under general anaesthesia.
Conditions
Interventions
Intervention1: Intravenous injection: Group P : Received Palonosetron 0.075 mg i.v
Group D : Received Dexamethasone 8 mg i.v, diluted in normal saline
Group P + D : Received Palonosetron 0.075 mg and
Sponsors
Dr Neha Sadhoo
Eligibility
Inclusion criteria
Inclusion criteria: Adult ASA Grade I or II patients, who underwent elective laparoscopic surgeries under general anaesthesia.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating females 2. Patients older than 60 years or younger than 18 years of age 3. Patients with a history of central nervous system or neuromuscular disease 4. Patients with ASA physical status grade > II 5. Morbidly obese patients 6. Patients with hepatic, renal or cardio-respiratory disease 7. Patients with gastro-esophageal reflux 8. Patients with history of drug or alcohol abuse 9. Patients with known hypersensitivity to either Palonosetron or Dexamethasone 10. Patients with previous history of PONV or motion sickness 11. Patients receiving chemotherapy or radiotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Incidence of PONV- using a 3- point scale ( 0-none, 1-nausea, 2- vomiting ). 2. Number of patients needing rescue antiemetic treatment. 3. Pain intensity scores- obtained with VAS test.Timepoint: 0, l, 2, 4, 8 and 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Heart rate 2. Blood pressure 3. Respiratory rate 4. Incidence of nausea and vomiting 5. Visual analogue scale scoreTimepoint: 0, l, 2, 4, 8 and 24 hours | — |
Countries
India
Contacts
Public ContactDr Pavan Gurha
Guru Gobind Singh Indraprastha University
Outcome results
None listed