Health Condition 1: null- Pregnant women with severe preeclampsia
Conditions
Interventions
Intervention1: 12 hours of magnesium sulfate: Patients in this group will have magnesium sulfate administered for 12 hours after delivery.Mgso4 to be given 14 gm loading dose(5gm in each buttock IM an
Sponsors
DirectorPGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1. Women with severe-preeclampsia, diagnosed during ante partum, intrapartum, or postpartum, are eligible for inclusion after delivery. A diagnostic criterion for severe preeclampsia includes: • sustained systolic blood pressure of >=160 mm Hg; • sustained diastolic blood pressure of >=110 mm Hg; • proteinuria >3 + on dipstick or >=5 g/24- hour urine collection; • oliguria (urine output • the presence of persistent headache, visual disturbances, or epigastric or right upper quadrant pain; thrombocytopenia ; impaired liver function; pulmonary edema or cyanosis; • fetal growth retardation; • or superimposed severe pre-eclampsia with pre-existing chronic hypertension. 2. Agree to comply with study procedures; 3. > 18 years of age; 4. Give informed consent for study participation
Exclusion criteria
Exclusion criteria: Exclusion Criteria • Associated maternal diseases; • Use of illicit drugs or other medications that might interfere with maternal hemodynamics; • Contraindications to the use of magnesium sulfate: drug hypersensitivity, oliguria with urine output below 25ml/h; anuria (absent urine output), myasthenia gravis. • Comatosed patients • Pulmonary oedema • Oliguria • Patients who have received MgSO4, Phenytoin, Diazepam before coming to hospital • Intra cranial bleeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Maternal: Recurrence of fits, signs of magnesium toxicity like loss of knee jerk, respiratory depression, and any other maternal complications like coagulation failure, oliguria, renal failure, and pulmonary oedema will be recorded. Details of labour and delivery will be recorded.Timepoint: Outcome will be assed till48 hours of delivery | — |
Secondary
| Measure | Time frame |
|---|---|
| 2. Serum Magnesium level in maternal bloodTimepoint: at 5 mins, 4 hrs, 12 hrs and 24 hrs | — |
Countries
India
Contacts
Public ContactDr Pradip Kumar Saha
PGIMER, Chandigarh
Outcome results
None listed