Health Condition 1: null- Patients with status epilepticus
Conditions
Interventions
Intervention1: Sodium Valproate (SVA) (group 1): SVA will be compared against LVM
SVA group will receive sodium valproate 25 mg/kg IV in 100 mL saline infused at speed of 6mg/kg/min over 15 minutes fo
Sponsors
NON FUNDED
Eligibility
Inclusion criteria
Inclusion criteria: • Patients with GCSE (more than 10 minutes of continuous convulsive seizure activity or two or more sequential seizures without full recovery of consciousness in between seizures), irrespective of etiology. • Willing to participate. • Age group more than 60 years.
Exclusion criteria
Exclusion criteria: • Not willing accompanying relatives/friends • Patients having non-convulsive SE • Liver failure, renal failure, cardiac disease (based on clinical judgment, available lab reports, ECG at presentation) • Requiring urgent neurosurgical intervention. • H/O allergy to drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Control of seizuresTimepoint: Control of seizures will be assessed in each subjects as soon as the study drug infusion is over. Subject will be continuously reassessed till primary outcome is arrived at. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality and MorbidityTimepoint: Recruitment to 1 month | — |
Countries
India
Contacts
Public ContactSANJIB SINHA
NIMHANS
Outcome results
None listed