Health Condition 1: null- Children aged â?¤ 12 years admitted in PICU for mechanical ventilation with anticipated to require sedation for more than 24 hours.
Conditions
Interventions
Intervention1: Dexmedetomidine: Starting dose of dexmedetomidine will be 0.2 microgram/kg/hour without loading dose. Trial drug will be hiked up in range of 0.05 to 0.1 (0.25 to 0.5ml/hr) microgram/kg
Sponsors
Director JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 24 hours.
Exclusion criteria
Exclusion criteria: 1. Children with unstable hemodynamics at the time of enrollment (Mean arterial blood pressure =2 vasoactive therapy support and/or requiring on going resuscitation) 2. Children requiring mechanical ventilation for neuromuscular diseases 3. Children with severe central nervous system pathology like raised intracranial pressure irrespective of causes, acute cerebrovascular accident, status epilepticus etc. 4. Children with developmental delay 5. Children with evidence of myocardial dysfunction (ejection fraction 6. Requiring dialysis irrespective of type at the time of enrollment. 7. Received general anesthesia 24 hours prior to or planned after the start of study drug infusion. 8. Children with severe liver pathology like acute liver failure, hepatic encephalopathy, chronic liver diases etc. 9. Children with trauma and burns as an admitting diagnosis. 10. Children requiring neuromuscular blockade infusion other than for intubation.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Adverse effects of the study drugs.Timepoint: at end of infusion.;Length of PICU and hospital stayTimepoint: at the discharge from PICU and hospital.;Number of intermittent dose requirements of opioids (Fentanyl and/or morphine) for sedation/analgesiaTimepoint: at the time of extubation and or out from mechanical ventilation | — |
Primary
| Measure | Time frame |
|---|---|
| To compare the length of mechanical ventilation children in those receiving dexmedetomidine as compared to those receiving midazolam.Timepoint: At the time of Extubation and or out of mechanical ventilation. | — |
Countries
India
Contacts
Public ContactDR R RAMESH KUMAR
ASSISTANT PROFESSOR
Outcome results
None listed