The use of flupertine analgesic in spine surgery

Role of flupertine as a perioperative analgesic in patients undergoing spinal surgery: A prospective, randomized controlled study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2016/04/006889

Enrollment

Registered

2016-04-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA grade I or II patient, Non diabetic, Non hypertensive and require spine surgery

Interventions

Intervention1: Flupertine: Patients will be received flupertine 100 mg orally, 1 hour preoperatively and 12 hours postoperatively with sips of water. Control Intervention1: Similar looking vitamin B c

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA grade I and II 2.Non hypertensive and non diabetic 3.Scheduled for spinal surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1.Patients with known sensitivity to study drugs 2.History of drug or alcohol abuse, 3.Morbid obesity (body mass index >40), 4.History of chronic pain or daily intake of analgesics 5.Oral anticoagulant use (warfarin) 6.Patients with bleeding diathesis 7.Impaired kidney or endocrinal functions 8.Pregnant patients and 9.Psychiatric patients

Design outcomes

Primary

Measure	Time frame
The total fentanyl consumptionTimepoint: First 24 hour postoperative period	—

Secondary

Measure	Time frame
Visual Analogue Score (VAS) Severity of postoperative nausea and vomitingTimepoint: VAS at 0,2,4,6,12 and 24 hour	—

Countries

India

Contacts

Public ContactDr Vinit Kumar Srivastava

Apollo Hospitals Bilaspur

drvinit75@gmail.com9755557539

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026