comparison of 2 drugs to manage brain swelling in patients with head injury

A comparative study of 3% Hypertonic saline and 20% mannitol in the treatment of refractory post traumatic intracranial hypertension

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2016/04/006829

Enrollment

Registered

2016-04-18

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Acute Traumatic Brain injury

Interventions

Intervention1: mannitol: 20% mannitol frequency:every time ICP increases 20 mmHg route:intravenous Duration: 6 days Control Intervention1: Hypertonic saline: 3% hypertonic saline frequency:every tim

Eligibility

Inclusion criteria

Inclusion criteria: within 24 hours of traumatic brain injury

Exclusion criteria

Exclusion criteria: Pregnancy GCS 3 Absent brainstem reflexes

Design outcomes

Primary

Measure	Time frame
Change in the intracranial pressureTimepoint: every 30 minutes	—

Secondary

Measure	Time frame
change in cerebral perfusion pressureTimepoint: daily for six days	—

Countries

India

Contacts

Public ContactAnirudh TJ

NIMHANS

gsuma123@yahoo.com9480829727

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026