Health Condition 1: null- Acute pyelonephritis Health Condition 2: N390- Urinary tract infection, site notspecified
Conditions
Interventions
Intervention1: 7 days antibacterial treatment: In the intervention arm, patients admitted with acute pyelonephritis are given a total of 7 days of sensitive antibiotic/antibiotics. The choice of the a
Sponsors
Department of Medicine Jawaharlal Institute of Postgraduate Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Either sex aged >18 years, admitted for acute pyelonephritis, defined as fever of at least 38oC and at least one symptom or sign relating to the urinary tract such as flank pain, costovertebral angle tenderness, dysuria, urgency or frequency along with the microbiologic criteria (>=10 pus cells/hpf or dipstick leucocyte esterase test positive and a positive culture with >=10 5 CFU/ mL of urine). They should have improved with empirical or culture-guided antibiotic treatment and be afebrile for at least 48 hours by day 7 of antibiotic treatment.
Exclusion criteria
Exclusion criteria: •Catheter-associated UTI •Recurrent UTI •Obstructive uropathy •Residual bladder urine >100 ml •Acute or chronic prostatitis / prostatic abscess • Emphysematous PN/renal or perinephric abscess •Shock requiring vasopressors •Altered sensorium requiring intubation (GCS score •Acute lung injury requiring mechanical ventilation •Renal failure requiring RRT •Clinically manifest DIC •Pregnancy •Any immunosuppressive treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Re-treatment rates within 6 weeks (Due to clinical or microbiological failure) Timepoint: Re-treatment rates within 6 weeks (Due to clinical or microbiological failure) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Duration of hospital stay 2.Daily defined dose of antibiotics 3.Asymptomatic bacteriuria 4.Adverse affects of antibiotics Timepoint: 1. At the time of discharge 2.During the hospital stay 3. At 6 weeks 4. During the hospital stay | — |
Countries
India
Contacts
Public ContactDeepanjali S
JIPMER
Outcome results
None listed