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EFFICACY OF BENZYDAMINE HYDROCHLORIDE, A LOCALLY ACTING ANTI INFLAMMATORY SOLUTION, GARGLES, ON POST OPERATIVE COMPLICATIONS LIKE SORE THROAT, HOARSENESS OF VOICE AND COUGH FOLLOWING TRACHEAL INTUBATION.

STUDY OF THE EFFICACY OF BENZYDAMINE HYDROCHLORIDE (0.15%) GARGLES ON POST OPERATIVE SORE THROAT (POST), COUGH AND HOARSENESS OF VOICE FOLLOWING TRACHEAL INTUBATION

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/04/006792
Enrollment
200
Registered
2016-04-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Patients belonging in the age group of 16-60 undergoing surgery under general anesthesia

Interventions

Intervention1: Benzydamine hydrochloride: Benzydamine hydrochloride (0.15%) 15 ml diluted upto 30 ml in mineral water given to gargle for 30 seconds in the pre operative holding area 10 minutes prior

Sponsors

LOKMANYA TILAK MUNICIPAL MEDICAL COLLEGE AND GENERAL HOSPITAL SION
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing general surgical, gynaecological and orthopaedic procedures under General Anaesthesia. ASA grade I and II. Duration of surgery 1-3 hours. Patients with as well as without Naso-gastric (Ryleâ??s tube) in situ. (inserted post induction, intraoperatively)

Exclusion criteria

Exclusion criteria: Unwilling Patients. Mallampatti classification > 2. Patients with preoperative sore throat or URTI within last 7 days of surgery. Known allergies to Benzydamine Hydrochloride. All pregnant mothers. Patients with gastro-esophageal reflux/ regurgitation.

Design outcomes

Primary

MeasureTime frame
Sore throat, cough and HoarsenessTimepoint: 0, 2, 4, 24 hours postoperatively—

Secondary

MeasureTime frame
Intracuff pressure, heart rate and blood pressureTimepoint: Intraoperatively every 15 minutes;Side effectsTimepoint: intra and postoperatively—

Countries

India

Contacts

Public ContactDr Smita Madhusudan Gaikwad

Lokmanya Tilak Municipal Medical College and General Hospital

rupwatekanchan@rediffmail.com09833881591

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026