FindTrial
Sign In

To compare the effects of Dexmedetomidine and Lignocaine on intracranial and systemic pressure dynamics after chest physiotherapy and tracheal suctioning in patients with severe traumatic brain injury: A randomized, blinded pilot study

To compare the effects of Dexmedetomidine and Lignocaine on intracranial and systemic pressure dynamics after chest physiotherapy and tracheal suctioning in patients with severe traumatic brain injury: A randomized, blinded pilot study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/03/006770
Enrollment
60
Registered
2016-03-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- CRITICAL PATIENT

Interventions

Intervention1: betwen Dexmedetomidine and lignocaine: Dexmedetomidine 0.5 mcg/kg and Lignocaine 2 mg/ kg and after taking the required amount of drug, it will be diluted with 0.9 % NaCl to make total

Sponsors

AIIMS HOSPITAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Sixty patients of severe traumatic brain injury (TBI), between 18-60 years of age, admitted to neurotrauma intensive care unit (ICU), who are undergoing mechanical ventilation and having stable ICP ( = 90 mm Hg) will be enrolled for this prospective, randomized double blind study

Exclusion criteria

Exclusion criteria: Exclusion criteria will include patients having any chest injury interfering with effective chest physiotherapy ie. fractured ribs or fracture dorsal spine, percutaneous emphysema, presence of haemothorax, pneumothorax, or a chest drainage tube. Patients with history of severe cardio-respiratory disorders and those having hypotension (SBP < 90 mm Hg) or hypoxemia (PaO2 < 60 mm Hg) or SpO < 90% will also be excluded

Design outcomes

Primary

MeasureTime frame
To compare the effect of Dexmedetomidine and Lignocaine on intracranial and systemic pressure dynamics after chest physiotherapy and tracheal suctioning in patients with severe traumatic brain injuryTimepoint: NA—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public Contactshalendra singh

AIIMS NEW DELHI

drrajendrasinghchouhan@gmail.com9868398202

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026