Health Condition 1: null- Schizophrenia
Conditions
Interventions
Intervention1: Transcranial Direct Current Stimulation (tDCS): Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulatory brain stimulation technique that delivers low intensity,
1) a fade-in phase, ramps up the current to the desired intensity (20 s), 2) the stimulation phase that continues at a target intensity (typically 2 mA, for 20 min), and 3) a fade-out phase where curr
20 s). 4) 2 sessions/day 3 hours apart for 5 continuous days
Control Intervention1: Placebo arm of transcranial direct current stimulation (tDCS): For the sham tDCS condition, the actual stimulation o
Sponsors
National Institute of Mental Health and NeuroSciences
Eligibility
Inclusion criteria
Inclusion criteria: 1) Diagnosis of schizophrenia/schizophreniform disorder as per DSM-V criteria (Diagnostic and Statistical Manual for Mental Disorders, American Psychiatric Association, 2013); 2) Clinically Significant Auditory Verbal Hallucinations as defined by the Auditory Hallucination Rating Scale (Haddock et al 1999) items on frequency, duration and disruption each having a score >= 2; 3) Stable antipsychotic medication dose atleast for the past 4 weeks with no change in auditory hallucination severity; 4) Age: 18 â?? 45 years; 5) Both sexes; 6) Right Handedness and 7) Written informed consent.
Exclusion criteria
Exclusion criteria: 1) Features suggestive of psychiatric emergency (suicidal risk, aggression, excitement, catatonia, prolonged nutritional deprivation or any other status requiring intensive clinical care); 2) Any contraindication to tDCS procedure â?? (i) metal in the head, (ii) implanted brain medical devices, (iii) local lesion or injury in the scalp / head; 3) Any co-morbid psychiatric diagnosis; 4) Left Handedness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Improvement in auditory verbal halluciantion 2. Changes in hemodynamic response, fronto-temporo-parietal network connectivity 3. Profile of auditory processing efficiency 4. Impact of neuroplasticity gene polymorphismTimepoint: Assessments will be done twice, before starting tDCS and after completion of tDCS 5 days course | — |
Secondary
| Measure | Time frame |
|---|---|
| CognitionTimepoint: Assessments will be done twice, before starting tDCS and after completion of tDCS 5 days course | — |
Countries
India
Contacts
Public ContactDr Venkatasubramanian
National Institute of Mental Health and Neurosciences
Outcome results
None listed