Health Condition 1: null- Statge IV Oral Cavity Cancers(Borderline Resectable)
Conditions
Interventions
None listed
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: 1. Previously untreated borderline resectable oral cavity SCC i.e T4a lesions with skin induration. 2. Histological proven diagnosis of squamous cell cancer 3. Signed informed consent 4. Adequate organ function • Hematological- Hb > 9 g/dL, ANC >= 1.5 x 109/L, platelets >= 100 x 109/L. • Liver functions- bilirubin = 30 g/L. • Renal function- Creatinine 30 mL/min. • Performance score (KPS) > 80 or ECOG
Exclusion criteria
Exclusion criteria: 1. Distant metastasis present 2. Serious co-morbidities such as severe cardiac failure or severe pulmonary compromise or severe and active infections. 3. Locally advanced unresectable disease (T4b) or inoperable nodal disease 4. Patients not suitable for any chemotherapy. 5. Patient is currently enrolled in a clinical trial for another investigational therapy. 6. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate patterns of tumor response and impact on surgical margins following neoadjuvant chemotherapy (NACT) in locally advanced oral cavity tumors.Timepoint: At surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| NATimepoint: NA | — |
Countries
India
Contacts
Public ContactDr Anuja Deshmukh
Tata Memorial Hospital
Outcome results
None listed