Health Condition 1: null- parturients with singleton pregnancy at â?¥ 28weeks of gestation, admitted with diagnosis of severe pre-eclampsia and scheduled to receive Magnesium Sulphate therapy, before delivery
Conditions
Interventions
None listed
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: parturients with singleton pregnancy at >= 28weeks of gestation, admitted with diagnosis of severe pre-eclampsia and scheduled to receive Magnesium Sulphate therapy, before delivery, will be included in the study.
Exclusion criteria
Exclusion criteria: We will exclude the following patients from the study : a. Presence of ocular wound b. Prior ocular surgery c. Patient refusal d. Chronic hypertension e. Hyperthyroidism f. Severe pre-eclamptics already on MgSO4 therapy g. Presence of pre-existing chronic lung and/or cardiac diseases h. Presence of pre-existing chronic renal and/or hepatic diseases i. Presence of any chronic diseases of central nervous system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To observe the changes in ultrasonographically measured ONSD following MgSO4 treatment in severely pre-eclamptic parturients at pre-defined intervalsTimepoint: Prior to start of MgSO4 therapy and at 4hr, 12hrs and 24 hrs after start of therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Our secondary outcomes will include the following: 1. The incidence of raised ICP (ONSD5.0 mm) in severe pre-eclampsia prior to MgSO4 therapy. 2. Correlation of ONSD with serum magnesium levels at pre-defined time intervals. 3. Maternal haemodynamic changes following MgSo4 therapy. 4. Changes in neurological signs and symptoms following MgSO4 therapy. Timepoint: Prior to start of MgSO4 therapy and at 4hr, 12hrs and 24 hrs after start of therapy | — |
Countries
India
Contacts
Public ContactDr Nidhi Bhatia
PGIMER Sector 12 Chandigarh
Outcome results
None listed