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Effect of avoidance of nitrous oxide during anaesthesia in patients undergoing brain tumour surgery.

The effect of sevoflurane-air versus sevoflurane-nitrous oxide anaesthesia on length of ICU and hospital stay in patients undergoing cerebellopontine tumour surgery- a randomised controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2016/01/006574
Enrollment
50
Registered
2016-01-28
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Cerebellopontine angle tumours

Interventions

Intervention1: Nitrous Oxide: Nitrous Oxide with Oxygen (FiO2 0.4) with Sevoflurane Control Intervention1: Nitrous oxide: Nitrous oxide with Oxygen (FiO2 0.4) with Sevoflurane

Sponsors

Barkha Bindu
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I & II patients. Patients of cerebellopontine angle tumours posted for elective tumour excision surgery. Anticipated duration of anaesthesia more than 6 hours.

Exclusion criteria

Exclusion criteria: Refusal of consent. Patients with history of smoking. Haemodynamically unstable patients. Hb Evidence of pneumocephalus on CT scan. Patients with evidence of pneumothorax. Patients with bleeding disorders. Patients with preoperative GCS Patients with significant pulmonary disease, renal or hepatic disorders, unstable angina, uncontrolled diabetes or hypertension. Pregnant females. Patients operated upon in sitting position. Patients with BMI > 35.

Design outcomes

Primary

MeasureTime frame
To compare the mean duration of ICU stay and hospital stay.Timepoint: At time of discharge from ICU and at time of discharge from hospital

Secondary

MeasureTime frame
1. To compare intraoperative brain condition, emergence, duration of postoperative ventilation and GOS at discharge. 2. To compare the incidence of hemodynamic fluctuations and complications in the intraoperative and postoperative period. Timepoint: 1. During surgery and post operative period 2. During surgery and post operative period

Countries

India

Contacts

Public ContactMihir Prakash Pandia

AIIMS

pandiamihir@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026